Yes, you can skip Queen’s Blood in Final Fantasy VII Rebirth. It is an entirely optional minigame, and you are not required to play it to progress through the main story. However, skipping it means you will miss out on some side content and rewards, such as additional cards for your deck and the opportunity to participate in a Queen’s Blood tournament in Chapter 5.

Here are the key points to consider:

1. Optional Nature: Queen’s Blood is 100% optional and does not affect the main storyline.
2. Rewards: Playing Queen’s Blood rewards you with more cards and the chance to participate in a tournament, but the rewards are not crucial for completing the game.
3. Gameplay: The game provides a tutorial for Queen’s Blood, but you can skip it if you prefer not to play the minigame.
4. Strategies: If you decide to play, there are strategies to help you win, such as focusing on destroying cards and customizing your deck with various cards.

Ultimately, whether or not to play Queen’s Blood is up to personal preference. If you’re looking to focus on the main story and side quests, you can skip it without any significant impact on your overall experience.